조직공학용 스캐폴드의 강도 향상
Enhanced Strength of the Tissue Engineering Scaffold
김성민, 김광만, 이용근, 유창국, 이강식,
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김성민 ( Kim Sung-Min ) - 연세대학교 치과대학 치과생체재료공학교실
김광만 ( Kim Kwang-Man ) - 연세대학교 치과대학 치과생체재료공학교실
이용근 ( Lee Yong-Keun ) - 연세대학교 치과대학 치과생체재료공학교실
유창국 ( You Chang-Kook ) - 오스젠
이강식 ( Lee Kang-Sik ) - 서울아산병원
KMID : 0362220110380030321
Abstract
Calcium phosphate such as Hydroxyapatite (HA) and beta tri-calcium phosphate (β-TCP), due to its excellent biocompatibility and bioactivity, is widely used in the clinic of orthopedic as well as dental applic ations. The HA h as g ood biologic al p roperties like n on-immunogenicity, n on-inflammatory behavior, high osteoconductivity and osteoinductivity. The β-TCP shows the good biocompatibility and biodegradability. Especially, calcium phosphate scaffolds have interconnected pores that provide a favorable environment for bone i ngrowth, o sseointegration a nd b lood s upply. T he c alc ium phosphate sc affold, however, h as brittle property and low strength. The purpose of this study was to investigate the effects of a kind and each amount of binder and fabrication methods for high compressive strength of calcium phosphate scaffold. At HA scaffold, the maximum compressive strength was performed when combined binder of 3 wt% of polyvinyl alcohol and 1 wt% of methyl cellulose was selected. The β-TCP scaffold fabricated by novel template- casting has high compressive strength than sponge method.
키워드
Calcium phosphate;Compressive strength;Hydroxyapatite;Scaffold;Tri-calcium phosphate
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